… with AM to cause lung toxicity. The objective of this study was to determine the type …
cytotoxic interaction between AM and DEA in HPL1A human peripheral lung epithelial cells. …

… Therefore, a RAS-independent mechanism seems to be responsible for AM and DEA
cytotoxicity in nontransformed human lung epithelial cells; however, our findings do not preclude …

… amiodarone-induced pulmonary toxicity. In cultured HPL1A human peripheral lung epithelial
cells, … h of incubation, indicating that the HPL1A cell culture model can be used to study the …

… antiarrhythmic amiodarone (AM) and its metabolite desethylamiodarone (… cytotoxic for other
pulmonary cell types. Furthermore, we show that a significant component of the cytotoxicity is …

… pulmonary fibrosis. Susceptibilities of different hamster lung cell types to AM-induced cytotoxicity
… AM (1 00 and 200 bM)induced cytotoxicity was significantly greater in hamster alveolar …

… Both amiodarone and desethylamiodarone tend to … mTOR inhibition in H460 human lung
epithelial cells. This study is … aggravated the cytotoxicity of amiodarone in H460 cells, whereas …

… in AIPT, were susceptible to the toxicity of AM and N-desethylamiodarone (DEA), a major …
event in AM-induced cytotoxicity in pulmonary epithelial cells. Cytoplasmic translocation of …

… Amiodarone, an antiarrhythmic drug toxic toward the lung, is … mono-N-desethylamiodarone
(MDEA), di-N-desethylamiodarone (DDEA), and … and rat alveolar epithelial cells. Am J Physiol …

… , amiodarone is metabolized to N-desethylamiodarone, an … ‘cytotoxic’ effect to type II
pneumocytes, as well as other cells … shown that amiodarone induces alveolar epithelial cell (AEC…

… 1), it is possible that both amiodarone and desethylamiodarone ex… cytotoxic and suppressor
function;" In the microenvironment of the alveolar capillary structure, lung parenchymal cells …